PI3K signaling refers to the phosphoinositide 3-kinase signaling pathway, which plays a critical role in regulating various cellular processes such as cell growth, proliferation, survival, and metabolism. PI3K is a family of enzymes that phosphorylate inositol lipids in the cell membrane, leading to the activation of downstream signaling cascades, particularly the Akt/mTOR pathway. Dysregulation of PI3K signaling has been implicated in various diseases, including cancer, diabetes, and immune disorders. Research in this area focuses on understanding the molecular mechanisms underlying PI3K signaling, as well as developing novel therapeutic strategies targeting this pathway for the treatment of diseases.